Effect of Yupingfeng granule assisted fluticasone propionate nasal spray on patients with AR and its regulation on IL-5, ICAM-1 and ECP

Qiao, Yanming ; She, Xiumei ; Fan, Yuling Fan ; Yuan, Qian ; Bai, Yunyun

Abstract

The present investigation deals with the effect and mechanism of Yupingfeng granule assisted Fluticasone propionate nasal spray in the treatment of patients with allergic rhinitis (AR). Total of 140 patients with AR treated in Yulin Hospital of Traditional Chinese Medicine from December 2019 to July 2020 have been selected for clinical trial. The patients in traditional Chinese medicine (TCM) group were treated with Yupingfeng granule plus Fluticasone propionate nasal spray, while those in routine group are treated with Fluticasone propionate nasal spray. The remaining basic treatment in the two groups remained the same, with 60 patients in each group. Symptom, sign score, TCM syndrome score, quality of life score, interleukin-5 (IL-5), intercellular adhesion molecule-1 (ICAM-1), eosinophil cationic protein (ECP) levels in peripheral blood and clinical treatment effect have been compared between two groups before and after treatment. Before treatment, there is no significant difference in the scores of symptoms, signs and total scores between the two groups; after treatment, these were lower than those of the routine group. There is no significant difference in the scores of TCM symptoms between the two groups (P> 0.05) before treatment, while after treatment; these are lower than those of the routine group. The levels of IL-5, ICAM-1 and ECP in the peripheral blood of the patients in the two groups have been compared, and there is no significant difference between the two groups before treatment while after treatment, the levels of IL-5 and ECP in the peripheral blood of the patients in TCM group were lower than those in the routine group, and the difference had statistical significance. Yupingfeng granule assisted Fluticasone oropionate nasal spray can effectively relieve the clinical symptoms of patients with AR, improve the quality of life, regulate the levels of IL-5 and ECP in peripheral blood and improve the clinical effect.

Keyword(s)

Allergic rhinitis; Fluticasone propionate; Immunomodulation; TCM; Yupingfeng granules


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