Efficacy of Manjistha and Ginger Powder in Extending the Lifespan of Drosophila melanogaster

Naorem, Anjana Singha; Thongatabam, Bijaya ; Aggarwal, Prerna ; Gupta, Gunjan ; Raza, Amber ; Yadav, Anamika

Abstract

Ageing is a condition of deterioration of the physiological functions necessary for survival and fertility over time. It is found to be due to cellular damage caused by reactive oxygen species produced during normal metabolism. Effect of manjistha and ginger were tested to see any effect on the lifespan of Drosophila melanogaster. Significant upsurge in the life span of flies reared on manjistha and ginger supplemented media was observed. These plant powders were observed to thwart the oxidative stress caused by paraquat, a potent herbicide and model neurotoxicant. Upon paraquat treatment, mortality rate of 12% and 8% was observed in male and female flies respectively that were reared on manjistha supplemented media whereas mortality of 100% and 92% were observed in male and female flies respectively when reared on control media. The present study suggests potential benefits on the longevity of the flies by the dietary supplementation with ginger and manjistha, especially in the oxidative stress condition. These findings should be further examined to identify active components in these plant products that show its manifestation on the well-being of the fly.


Keyword(s)

Antioxidants; Drosophila; Ginger; Lifespan; Manjistha; Paraquat


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