Heavy metal and miRNA analysis in venous and wet-cupping blood taken simultaneously from female migraine patients

Alp, Hayriye baltaoğlu; Yerlikaya, Hümeyra ; Unat, Berivan


Today, population growth, urbanization and industrialization have increased the contact of allliving things with heavy metals.With this study, we believe that the laboratory partial of the treatment with wet-cupping in migraine disease will be clarified. The aim of this study is to measure the levels of heavy metal and micro RNAs that are thought to play a act in migraine pathophysiology in female migraine patients and to reveal their differences compared to the control group.This study was carried out on a group of healthy women that were volunteer migraine patients who had applied to xxx university, Traditional / Complementary Medicine Center and on a control group. This study was conducted in 2018- Necmettin Erbakan University Konya Meram MedicalFaculty GETAT Center. This is a cross-sectional study. Group 1: control group women venous blood; Group 2: migraine women venous blood group; Group 3: women control group wet-cupping: Group 4: women with migraine group wet-cupping.In our study, Pb, Hg andNi wet-cupping blood rates were higher in venosus blood. The plasma miR-21 level of Group 2 was significantly higher than that of group 3 (p< 0.05). This result shows that giving venous blood is insufficient for heavy metals removal; wet-cupping is more effective. Prolong shield to Pb is happening at the same time with headaches. A closelylink between migraines and low Mg has been discovered.
Low Mg, which might inhibit the production of nitricoxide, increases the distribution of substance P, so causing the narrow of cerebral vessels.


Heavymetals; Migraine; miRNA; Women

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