Effect of cinnamon supplementation on resistin and ghrelin in obese diabetic men

Sfar, Myriam ; Hfaiedh, Kmar Ben; Mahrez, Kamel Ben; Skhiri, Hajer Aounallah; Rayana, Chihab Ben; Chemli, Rachid ; Mami, Faika Ben; Slama, Fethi Ben


The object of this study was to determine the effect of Cinnamomum zeylanicum (cinnamon) on glycemic/lipid balance, resistin and ghrelin. 84 obese Type 2 diabetic patients were assigned in 2 groups which consumed 8 g and 4 g of cinnamon powder. Anthropometric, hormonal and biochemical parameters were measured before and after 10 weeks of treatment. We found that cinnamon decrease BMI and waist circumference respectively of -5.52±1.47 kg/m² and -10.72±6.12 cm for group 2 of and a decrease of -4.45±1.46 kg/m² and -6.86±5.5 cm in group 1. Our results also showed a decrease of the glucose level of -1,173±0, 75 mmol/L in group 2 and -0, 8932±0, 72 mmol/L in group 1 and a decrease of insulin levels
of -3.24±2.85 μUI/L in group 2 and -2.54±2.8 μUI/L in group 1. The assays showed that resistin secretion decreased
by -2.08±1.09 ng/mL for the 8 g dose and -1.59±0.926 ng/mL for the 4 g dose, and there was an increase in ghrelin secretion of +1.55±2.21 μg/mL for the 8 g dose and + 2.49±1.13 μg/mL for the 4 g dose.

The results confirmed the anti-hyperglycemic and hypolipidemic effects of cinnamon opening a new approach to studying how the compounds derived from certain spices regulate the endogenous release of hormones such as ghrelin and resistin for therapeutic intervention.


Cinnamon; Diabetes; Ghrelin; Obesity; Resistin

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