Antioxidant, anti-inflammatory and antiapoptotic effects of Naringin on cardiac damage induced by cisplatin

Gelen, Volkan ; Şengül, Emin

Abstract

Cisplatin (CP), an anticarcinogenic agent, is declared to have side effects including cardiotoxicity. Naringin (NA), a flavonoid, was shown to have strong antioxidant structure and anti-inflammatory characteristics. Pupose of our study was to investigate the protective effects of NA on Caisplatin-induced cardiotoxicity. Sprague-Dawley male rats in the range of 220-250 g were exerted in this experimental studies. The rats used in experiment separated to 5 groups (10 in each one): Control, CP, NA100+CP, NA200+CP and NA200. The groups received drugs for 14 days. The rats were decapitated on 15th day. Cardiac tissue and blood samples was taken. When the cardiac tissue was assessed for oxidative stress, a prominent increase was found in CP group than other groups (p<0.05). It was assigned that serum CK, CK-MB, LDH, AST and ALT activities and levels of cytokines (TNF-alpha, IL-8, IL-1β and IL-6) in the cardiac tissue, a significant increase was found in CP group than control group (p<0.05). In both control and NA200+CP groups, similar values obtained for comparative values. Caspase 3 and iNOS activity were significantly raised for CP group, compared to NA100+CP and NA200+CP, control groups. NA has a protective effect on CP-induced heart injury. It has been determined that NA prevents CP-induced apoptosis in the heart.

Keyword(s)

Cardiotoxicity; Caspase 3; Cisplatin; Ciytokine; iNOS; Naringin; Rat

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