Identification of therapeutic targets for controlling COVID-19 pandemic by traditional system of Ayurvedic medicines: A systematic review

COVID-19 is a severe respiratory disorder caused by the SARS COV-2 virus that involves limited innate immunity. Numerous publications have suggested that plants/minerals used in the Traditional system of Ayurveda, has revealed much about the biology of COVID-19. One theory is that combination of anti viral, anti inflammatory, agents activating immune cells, anti toxic herbs and metals may be helpful for severe acute respiratory syndrome coronavirus infection. Anti viral Drugs used for COVID-19 are those which blocks RNA synthesis, virus invasion, bind to receptor proteins on the surface of cells, cell cycle protein, and physiological and pathological processes inhibitor. Anti-inflammatory drugs used for COVID-19 re those which controls transcription of DNA, cytokine production, break down the basement membrane, regulate outer mitochondrial membrane permeability, controlling the host cell life, stimulates activated B-cell and T-cell proliferation, virus dissemination, a slowdown of cell metabolism or secretion of cytokines. Drugs which is having role in the innate immunity, inhibits ROS, enhances cell lifespan, activates macrophages, physiological effects on cells activates the Lung resident immune cells. The focus of this review is to elucidate the Ayurvedic pharmacological properties with their therapeutic targets.

Dash, Manoj Kumar; Joshi, Namrata ; Tripathi, Yamini Bhusan

Abstract

COVID-19 is a severe respiratory disorder caused by the SARS COV-2 virus that involves limited innate immunity. Numerous publications have suggested that plants/minerals used in the traditional system of Ayurveda, has revealed much about the biology of COVID-19. One theory is that combination of anti viral, anti inflammatory, agents activating immune cells, herbs and metals may be helpful for severe acute respiratory syndrome coronavirus infection. Anti-viral drugs used for COVID-19 are those which block RNA synthesis and virus invasion, and bind to receptor proteins on the surface of cells, cell cycle protein, and physiological and pathological processes inhibitor. Anti-inflammatory drugs used for COVID-19 are those which controls transcription of DNA, cytokine production, break down the basement membrane, regulate outer mitochondrial membrane permeability, controlling the host cell life, stimulates activated B-cell and T-cell proliferation, virus dissemination, a slowdown of cell metabolism or secretion of cytokines. Drugs which is having role in the innate immunity, inhibits ROS, enhances cell lifespan, activates macrophages, physiological effects on cells activates the Lung resident immune cells. The focus of this review is to elucidate the Ayurvedic pharmacological properties with their therapeutic targets.

Keyword(s)

Ayurveda system of Medicine; Anti-inflammatory; Anti-viral; Immune cells; SARS-CoV-2; Therapeutic target


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