Hepatoprotective activity of Mitragyna speciosa Korth. on Liver Damage Caused by Tuak

 

Panjaitan, Ruqiah Ganda Putri; Mery, Monalisa Wendy

Abstract

This study aims to evaluate the protection and restoration capacity of kratom leaves extracts on liver damage caused by tuak. Group A consist of 12 mice and divided into A1 administered 0.5 mL/20 g body weight aquadest, A2 administered kratom leaves ethanol extract at dose 0.29 mg/20 g body weight and A3 administered silymarin at dose 0.70 mg/20 g body weight on days 1 to 7, then continued given tuak at dose 0.26 mL/20 g body weight on days 8 to 14. Group B consist of
12 mice and divided into B1, B2, and B3, on days 1 to 7 they were administered tuak at dose 0.26 mL/20 g body weight then continued with aquadest at dose 0.5 mL/20 g body weight (B1), kratom leaves ethanol extract at dose 0.29 mg/20 g body weight (B2), and silymarin at dose 0.70 mg/20 g body weight on days 8 to 14 (B3). The average levels of ALT enzyme in the treatment groups respectively showed 29.13±0.40 U/L (A1); 25.25±0.69 U/L (A2); 20.51±1.00 U/L (A3) and 31.20±0.47 U/L (B1); 26.95±0.62 U/L (B2); 23.31±0.89 (B3) (p<0.05). Whereas, the average levels of AST respectively at 34.23±0.63 U/L (A1); 28.64±0.40 U/L (A2); 25.13±0.83 U/L (A3) and 35.69±0.63 U/L (B1); 30,83±0.63 (B2); 27.31±0.83 (B3) (p<0.05). The average scoring for the treatment groups resulted in 2.67; 2.33; 1.33 respectively A1, A2, and
A3 (p<0.01) and 2.00; 0.67; 0.33 respectively B1, B2 and B3 (p<0.01). It is concluded that kratom leaves are not effective
to protect and to restore the liver.

 


Keyword(s)

Kratom leaves, Liver histopathological, Serum enzymes, Tuak

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