Pharmacology and biochemistry behind the use of natural herbs to control arthritis – A review

Mitra, Sankar P

Abstract

The article provides information regarding pharmacological and biochemical aspects of few herbs (Turmeric, Ginger, Capsicum, Devils’ claw, Meadowsweet, Willow, Evening primrose, Juniper, Nettle and Boswellia) that are commonly used in treating arthritis and associated inflammations. All of them have substantialability to reduce pain and inflammation without the side effects. Distinctively, the herbs synthesize multiple phyto-chemicals that are chemically categorized as terpenes, flavins and tannins offering irrefutable impact on the patients providing significant relief. Advantageously, due to less side effects, the presence of multiple anti-inflammatory components insists patients to rely on herbs as a viable alternative in place of commercial therapeutic drugs available to control the arthritis. Many also use herbs as a supplement for additional therapeutic measure. It is proven that naturally occurring terpenes, sterols, flavins and polyphenols exert significant immune modulatory function to inhibit the inflammatory processes normally observed owing to the eruption of arthritis. So, by preventing the actions of NF–κβ and other associated factors these herbs control the arthritic problems. The co-presence of numerous ingredients in a single species often synergize the anti-inflammatory encounter while also preventing the generations of free radicals/ ROS which normally accelerate the inflammatory process. Intermittent assistance is occasionally provided by the few fatty acids within some herbs for their metabolic conversion to PGE1 or TXA1 adding additional preventive role. So less side effects along with the traditionally proven positive records ensure many to use herbs while managing the arthritic problems.

Keyword(s)

Anti-inflammatory actions; Arthritis; Flavins; Herb; Tannins; Terpenes.


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