Effect of Radix Platycodonis and Radix Cyathulae in Xuefu Zhuyu Tang on tissue
distribution of paeoniflorin in blood-stasis mice by HPLC: Experimental
evidence on Shi ingredients in traditional formula compatibility

Verma, Charu ; Huang, Wei ; Chen, Yunhui ; Tang, Shiyun ; Liu, Xinglong ; Zhang, Xiaodan ; Wan, Peng ; Tang, Songqi


Xuefu Zhuyu Tang (XFZY), a famous formula in traditional Chinese medicine, has been demonstrated to show good
therapeutic effects on diseases caused by blood stasis syndrome. Two of its eleven herbs, Radix Platycodonis and Radix
Cyathulae, have been considered as Shi ingredients in the hierarchy of traditional formula compatibility and proven
possessing synergistic properties that strengthen the formula's potency of activating blood circulation and resolving blood
stagnation. However, its mechanism is still not clearly elucidated. In our previous study, we observed their effects on
paeoniflorin pharmacokinetics of XFZY in rats. In this study, we continued by detecting and comparing their effect on the
tissue distribution of paeoniflorin after oral administration of XFZY and its three variants (XFZY without Radix
Platycodonis or/and Radix Cyathulae) in blood-stasis mice via HPLC assay. The results indicated that combining usage of
Radix Platycodonis and Radix Cyathula increased the distribution of paeoniflorin in the lung and kidney and introduced the
paeoniflorin into the liver, spleen and heart. It might explain their synergistic properties that strengthen the formula's effect
of invigorating blood and dissolving stasis and provide experimental evidence to understand the pharmacological effects of
Shi herbs in the hierarchy of traditional formula compatibility.


Blood stasis syndrome; Paeoniflorin; Radix cyathulae; Radix platycodonis; Shi ingredient; Tissue distribution; Traditional formula compatibility; Xuefu Zhuyu Tang

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